Preconditional Activation of Hypoxia-Inducible Factors Ameliorates Ischemic Acute Renal Failure
نویسندگان
چکیده
منابع مشابه
Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure.
Activation of hypoxia-inducible transcription factor (HIF) has been identified as an important mechanism of cellular adaptation to low oxygen. Normoxic degradation of HIF is mediated by oxygen-dependent hydroxylation of specific prolyl residues of the regulative alpha-subunits by HIF prolyl hydroxylases (PHD). It was hypothesized that inhibition of HIF degradation by either hypoxia or pharmacol...
متن کاملNormotensive ischemic acute renal failure.
Copyright © 2007 Massachusetts Medical Society. A cute renal failure is defined as a rapid decrease in the glomerular filtration rate, occurring over a period of minutes to days. Because the rate of production of metabolic waste exceeds the rate of renal excretion in this circumstance, serum concentrations of markers of renal function, such as urea and creatinine, rise. The causes of acute rena...
متن کاملActivation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney.
BACKGROUND Preconditional activation of HIF with specific prolyl-hydroxylase inhibitors (PHD-I) attenuates proximal tubular injury, induced by warm ischaemia/ reperfusion (Bernhardt, JASN, 2006). Distal tubular damage occurs in humans with acute kidney injury (AKI), in experimental contrast media-induced nephropathy (CIN), as well as in cell-free isolated perfused kidneys (IPKs). Since in the I...
متن کاملNephron heterogeneity in ischemic acute renal failure.
To uncover the reasons for reported internephron heterogeneity in acute renal failure (ARF) serial micropuncture experiments in norepinephrine-induced ARF and sham-infused control rats were carried out to investigate this phenomenon. Proximal tubular pressures (PT) were scattered at 24, 48, and 72 hr in ARF rats ranging from 4 to 42 mm Hg, but the majority were greater than the mean control val...
متن کاملCALL FOR PAPERS Renal Hypoxia Morg1 heterozygous deficiency ameliorates hypoxia-induced acute renal injury
Loeffler I, Wolf G. Morg1 heterozygous deficiency ameliorates hypoxia-induced acute renal injury. Am J Physiol Renal Physiol 308: F511–F521, 2015. First published December 30, 2014; doi:10.1152/ajprenal.00236.2014.—Acute kidney injury is a common complication of critically ill patients and may occur as a result of various factors and coexisting previous illnesses. Some pathophysiological respon...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2006
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2005121302